崔闻，男，天津人，特聘副教授。2019年在天津大学获理学博士学位，同年进入重庆医科大学生科院博士后工作站从事博士后研究。2022年出站，获评特聘副教授，在 “微尺度病原与治疗实验室”继续开展研究工作。主要通过结构生物学，生物化学等手段，研究在病原与宿主相互作用过程中发挥关键作用的蛋白质。作为项目负责人主持国家自然科学基金、重庆市科委等多项科研课题。作为第一/通讯作者（含共同）在PNAS, Protein & Cell, International Journal of Biological Macromolecule, Antiviral Research等期刊杂志发表原创性高水平论文。
联系方式：190559@cqmu.edu.cn
主要研究方向：
1.重要病原体的关键药物靶点的结构和功能；
2.病原体入侵宿主过程中二者之间相互作用的精确机制。
代表性论著（#第一作者，*通讯作者）：
1.Wen Cui#; Elisabeth Braun#; Wei Wang#; Jinhong Tang#; Yanyan Zheng#; Benjamin Slater; Na Li;Cheng Chen; Qingxiang Liu; Bin Wang; Xiu Li; Yinkai Duan; Yunjie Xiao; Ruijiao Ti; DominikHotter; Xiaoyun Ji; Lei Zhang; Jun Cui; Yong Xiong; Daniel Sauter*; Zefang Wang*; Frank Kirchhoff*;Haitao Yang*; Structural basis for GTP-induced dimerization and antiviral function of guanylatebinding proteins,Proceedings of the National Academy of Sciences of the United States ofAmerica, 2021, 118(15)
2.Wen Cui#; Haojun Huang#; Yinkai Duan#; Zhi Luo; Haofeng Wang; Tenan Zhang; Henry C Nguyen;Wei Shen; Dan Su; Xi Li; Xiaoyun Ji*; Haitao Yang*; Wei Wang*; Crystal structure of monkeypox H1phosphatase, an antiviral drug target,Protein & Cell, 2023,14(6):469-472.
3.Yunjie Xiao#; Hongli Chen#; Haofeng Wang#; Mengwen Zhang#; Xia Chen; Jason M. Berk; LilinZhang; Yi Wei; Wenling Li;Wen Cui; Fenghua Wang; Qianfan Wang; Can Cui; Ting Li; Cheng Chen;Sheng Ye; Lei Zhang; Xiaoyun Ji; Jinhai Huang; Wei Wang*; Zefang Wang*; Mark Hochstrasser*; HaitaoYang*; Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmicincompatibility factors,Proceedings of the National Academy of Sciences of the United States ofAmerica, 2021, 118(41)
4. Deping Wang#; Rong Zhao#; Haofeng Wang#; Meiyue Wang; Wenshu Hu; Mengmeng Lin; Wen Shu; Yaojun Sun; Jimin Cao*;Wen Cui*; Xin Zhou*;Crystal structure of mRNA cap(guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors,International Journalof Biological Macromolecules, 2023, 253.
5.Tenan Zhang#; Xiang Chen#; Chengcheng Tao#; Haojun Huang; Zhi Luo; Mengmeng Liu*;Wen Cui*;Wei Wang*; Structural and mechanistic insight into the phosphorylation reaction catalyzed by mpoxvirus thymidine kinase,Antiviral Research, 2025.
6. Mengmeng Lin#,Wen Cui#, Hongliang Tian#, Yan Zhang, Chen Chen, Xiaoyun Yang, Heng Chi, Zhongyu Mu, Cheng Chen, Zefang Wang, Xiaoyun Ji*, Haitao Yang*, Zhi Lin*. Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis.ACS Infectious Diseases, 2021, 8(1): 150-158.
在研项目：
1.国家自然科学基金青年项目,鸟苷酸结合蛋白(GBP)的自身激活及抗多种囊膜病毒的机理研究,82202505, 2023.1-2025.12, 30万,主持；
2.重庆市博士后科学基金项目,鸟苷酸结合蛋白(GBP)的自身激活及抗寨卡病毒的机理研究,2022NSCQ-BHX0556, 2022.8-2024.7, 10万,主持；
3.重庆市教育委员会科学技术研究项目,猴痘病毒潜在药物靶点的抑制剂发现及结构机制研究,KJQN202300442, 2023.10-2026.9, 4万,主持。
